The prevalence of childhood overweight and obesity in the United States has resulted in a number of school-based health interventions. This article provides a review of research that addressed childhood overweight and obesity in minority, U.S. elementary schools. All studies reported some benefits in health behaviors and/or anthropometric measures. Effectiveness was greater when program objectives were specific, implemented across the school environments, extended into the community, and were culturally relevant. Because minority school children are disproportionately affected by overweight and obesity and poor health behaviors, and since schools may be the primary setting to address childhood overweight and obesity in communities, school nurses can be an advocate for school-based programs and facilitate success.