Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

Chem Commun (Camb). 2011 Dec 14;47(46):12547-9. doi: 10.1039/c1cc15716g. Epub 2011 Oct 24.

Abstract

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry*
  • Drug Carriers / toxicity
  • HEK293 Cells
  • HeLa Cells
  • Histidine / chemistry*
  • Humans
  • Polyethyleneimine / chemistry*
  • Polyethyleneimine / toxicity
  • Transfection / methods*

Substances

  • Drug Carriers
  • Histidine
  • Polyethyleneimine