Abstract
A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Drug Carriers / chemistry*
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Drug Carriers / toxicity
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HEK293 Cells
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HeLa Cells
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Histidine / chemistry*
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Humans
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Polyethyleneimine / chemistry*
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Polyethyleneimine / toxicity
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Transfection / methods*
Substances
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Drug Carriers
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Histidine
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Polyethyleneimine