This review examines the global empirical literature regarding disclosure of parental HIV infection to children. Thirty-eight articles published in English-language journals prior to 2011 were retrieved and reviewed regarding disclosure process, reasons for disclosure/non-disclosure and impacts of disclosure/non-disclosure. Disclosure rate was relatively low worldwide. The decision making of disclosure or non-disclosure was mainly affected by children's development level, stigma, consideration of children's benefits, and parenting practices. Unintentional and forced disclosures were common. Findings regarding the impacts of disclosure/non-disclosure were mixed but disclosure tended to have long-term positive impacts on the well-being of children, parents and family in general. This review underscores the importance of developing evidence-informed developmentally and culturally appropriate interventions to assist HIV-positive parents to disclose their HIV status to children, particularly in low-resource settings.