Mycobacterium tuberculosis "Beijing" epidemics: a race against mutations?

P Bhatter; A Chatterjee; N Mistry

doi:10.1016/j.tube.2011.09.004

Mycobacterium tuberculosis "Beijing" epidemics: a race against mutations?

Tuberculosis (Edinb). 2012 Jan;92(1):92-4. doi: 10.1016/j.tube.2011.09.004. Epub 2011 Oct 19.

Authors

P Bhatter¹, A Chatterjee, N Mistry

Affiliation

¹ The Foundation For Medical Research, 84-A, R.G.Thadani Marg, Worli, Mumbai 400018, India.

PMID: 22015174
DOI: 10.1016/j.tube.2011.09.004

Abstract

Multi Drug Resistant Tuberculosis Beijing strains exhibit different drug-resistance mutations (DRM) in different locations. By comparing DRM in Beijing reported from Tuberculosis endemic and epidemic locations, we propose that DRM selected in a population cannot tolerate biologically available drugs in different populations resulting in further evolution through novel DRM.

Publication types

Letter

MeSH terms

Antitubercular Agents / pharmacology*
Epidemics
Humans
Mutation / drug effects*
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Tuberculosis, Multidrug-Resistant / drug therapy*
Tuberculosis, Multidrug-Resistant / epidemiology

Substances

Antitubercular Agents