Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7102-6. doi: 10.1016/j.bmcl.2011.09.106. Epub 2011 Oct 1.

Abstract

Glucose 9 and 2-deoxyglucose 10 were successfully synthesized and radiolabeled with [(99m)Tc(CO)(3)(H(2)0)(3)](+) intermediate in high yield. The complexes were characterized by HPLC and its stability with histidine over time was challenged. Cell uptake and biodistribution studies in melanoma-bearing C57BL/6 mice were performed. Both compounds showed accumulation in tumor tissue with high tumor-to-muscle ratios. Thus, D-glucose- and D-2-deoxyglucose-(99m)Tc complex could be considered as agents for melanoma diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Deoxyglucose* / chemistry
  • Deoxyglucose* / pharmacokinetics
  • Drug Stability
  • Glucose* / chemistry
  • Glucose* / pharmacokinetics
  • Melanoma / diagnosis*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Structure
  • Organotechnetium Compounds* / pharmacokinetics
  • Radiopharmaceuticals* / pharmacokinetics
  • Tissue Distribution

Substances

  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Deoxyglucose
  • Glucose