Crassocolides N-P, three cembranoids from the Formosan soft coral Sarcophyton crassocaule

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7201-4. doi: 10.1016/j.bmcl.2011.09.052. Epub 2011 Sep 29.

Abstract

Three new cembranoids crassocolides N-P (1-3), was isolated from the organic extract of a Formosan soft coral Sarcophyton crassocaule. These structures were elucidated on the basis of spectroscopic analyses and by comparison with those previously reported in literature. The cytotoxicity of these compounds toward various cancer cell lines has also been determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Survival / drug effects
  • Diterpenes / chemistry*
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Taiwan

Substances

  • Antineoplastic Agents
  • Diterpenes
  • crassocolide N
  • crassocolide O
  • crassocolide P