[Significance of the captopril test in the diagnosis of primary hyperaldosteronism --apropos of 4 clinical cases]

Rev Port Cardiol. 1990 Apr;9(4):333-7.
[Article in Portuguese]

Abstract

We describe four cases of primary hyperaldosteronism whose initial presentation was a moderate to severe hypertension. In three patients an adrenal adenoma was found; in another patient was due to unilateral adrenal hyperplasia. A good therapeutic response was achieved in all cases by unilateral adrenalectomy. The captopril test (Lyons version) proved useful to exclude essential hypertension and, may be, in distinguishing the new sub-types of primary hyperaldosteronism recently described. Indeed, only in the case of unilateral adrenal hyperplasia a fall in plasma aldosterone levels was observed. However, we feel that further investigation is needed to clarify this point.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aldosterone / blood
  • Captopril*
  • Female
  • Humans
  • Hyperaldosteronism / blood
  • Hyperaldosteronism / diagnosis*
  • Male
  • Middle Aged
  • Renin / blood

Substances

  • Aldosterone
  • Captopril
  • Renin