Hedgehog rushes to the rescue of the developing cerebellum

Sci Transl Med. 2011 Oct 19;3(105):105ps40. doi: 10.1126/scitranslmed.3003080.

Abstract

Premature birth often is associated with neurodevelopmental disabilities. In this issue of Science Translational Medicine, a pair of papers investigate--in patients and in a reliable animal model--the effects of glucocorticoids on cerebellar development after premature birth.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain Injuries / drug therapy*
  • Cerebellum / drug effects*
  • Cerebellum / growth & development*
  • Cerebellum / injuries*
  • Cyclohexylamines / therapeutic use*
  • Female
  • Glucocorticoids / adverse effects*
  • Hedgehog Proteins / agonists*
  • Humans
  • Male
  • Receptors, G-Protein-Coupled / agonists*
  • Smoothened Receptor
  • Thiophenes / therapeutic use*

Substances

  • Cyclohexylamines
  • Glucocorticoids
  • Hedgehog Proteins
  • Receptors, G-Protein-Coupled
  • SAG compound
  • Shh protein, mouse
  • Smo protein, mouse
  • Smoothened Receptor
  • Thiophenes