Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy

Roxanne E Kieltyka; Maartje M C Bastings; Geert C van Almen; Pol Besenius; Erwin W L Kemps; Patricia Y W Dankers

doi:10.1039/c1cc14728e

Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy

Chem Commun (Camb). 2012 Feb 1;48(10):1452-4. doi: 10.1039/c1cc14728e. Epub 2011 Oct 18.

Authors

Roxanne E Kieltyka¹, Maartje M C Bastings, Geert C van Almen, Pol Besenius, Erwin W L Kemps, Patricia Y W Dankers

Affiliation

¹ Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology (TU/e), PO Box 513, 5600 MB, Eindhoven, The Netherlands.

PMID: 22010132
DOI: 10.1039/c1cc14728e

Abstract

A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Macromolecular Substances / chemical synthesis
Macromolecular Substances / chemistry
Molecular Structure
Oximes / chemistry*
Particle Size
Peptides / chemistry*
Pyrimidinones / chemistry*
Surface Properties

Substances

Macromolecular Substances
Oximes
Peptides
Pyrimidinones