Abstract
Four novel spin-labelled combretastatin A-4 (CA-4) analogues were first synthesised in quantitative yield by reacting CA-4 with the corresponding nitroxyl radical. Their cytotoxic activities against A-549 (human lung cancer) and HePG-2 (human liver cancer) in vitro were evaluated, and the results indicated that these derivatives were more cytotoxic than the clinical drug irinotecan.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / pharmacology
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Hep G2 Cells
-
Humans
-
Molecular Structure
-
Stilbenes / chemistry*
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents
-
Stilbenes
-
fosbretabulin