Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery

Dong Bo Li; Mark Rogers-Evans; Erick M Carreira

doi:10.1021/ol2025313

Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery

Org Lett. 2011 Nov 18;13(22):6134-6. doi: 10.1021/ol2025313. Epub 2011 Oct 18.

Authors

Dong Bo Li¹, Mark Rogers-Evans, Erick M Carreira

Affiliation

¹ Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.

PMID: 22007769
DOI: 10.1021/ol2025313

Abstract

Step-economic and scalable syntheses of novel thia-azaspiro[3.4]octanes are reported. These spirocycles and some related intermediates can serve as uncharted multifunctional modules for drug discovery chemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aza Compounds / chemical synthesis*
Drug Discovery*
Molecular Structure
Octanes / chemical synthesis*
Spiro Compounds / chemical synthesis*
Sulfones / chemistry

Substances

Aza Compounds
Octanes
Spiro Compounds
Sulfones