The combination of increasing student enrollment in baccalaureate nursing programs and the faculty shortage has contributed to larger class sizes that may affect both student satisfaction and learning. The purpose of this study was to identify baccalaureate nursing students' satisfaction with enrollment in small and large nursing courses. The authors also sought to determine whether a significant difference existed between test scores of students enrolled in small and large nursing courses. A survey was completed by 110 students, and test scores were compared between students in a small and a large nursing class using analysis of variance. The findings indicated that perceived satisfaction of students was significantly higher for those enrolled in the small nursing course versus the large course; however, no significant difference was found between test scores. To improve student satisfaction that can positively affect student retention, further research is needed on class size in the nursing discipline.