Abstract
Pentameric ligand-gated ion channels (pLGICs) of the Cys loop family are transmembrane glycoproteins implicated in a variety of biological functions. Here, we present a solution NMR study of the extracellular domain of a prokaryotic pLGIC homologue from the bacterium Gloeobacter violaceus that is found to be a monomer in solution.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry*
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Bacterial Proteins / genetics
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Cyanobacteria / chemistry*
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Cyanobacteria / genetics
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Cysteine Loop Ligand-Gated Ion Channel Receptors / chemistry*
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Cysteine Loop Ligand-Gated Ion Channel Receptors / genetics
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Models, Molecular
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Molecular Dynamics Simulation
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Molecular Sequence Data
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Nuclear Magnetic Resonance, Biomolecular
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Protein Conformation
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Protein Structure, Tertiary
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Protein Subunits
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Receptors, Nicotinic / chemistry*
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Solutions
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Structural Homology, Protein
Substances
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Bacterial Proteins
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Cysteine Loop Ligand-Gated Ion Channel Receptors
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Protein Subunits
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Receptors, Nicotinic
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Recombinant Proteins
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Solutions