Abstract
Five new 9,10-anthraquinones (1-5) were isolated from an ethanol extract of the roots of Knoxia valerianoides. Their structures including absolute configuration of 1 were determined by spectroscopic analysis. Compounds 4 and 5 showed moderate activity against nitrogen oxide production in macrophages induced by lipopolysaccharide, at 10(- 5) M, with inhibition ratios of 50.4 ± 3.6 and 41.7 ± 2.1%, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages, Peritoneal / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rubiaceae / chemistry*
Substances
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Anthraquinones
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Drugs, Chinese Herbal
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Lipopolysaccharides
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Nitric Oxide