Experimental cardiac hypertrophy induced by oral administration of mineralocorticoid and saline in rats

Angiology. 2012 Aug;63(6):416-9. doi: 10.1177/0003319711423529. Epub 2011 Oct 17.

Abstract

We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / toxicity
  • Cardiomegaly / chemically induced*
  • Cardiomegaly / diagnosis
  • Cardiomegaly / physiopathology
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Fludrocortisone / administration & dosage
  • Fludrocortisone / toxicity*
  • Heart Ventricles / drug effects*
  • Heart Ventricles / physiopathology
  • Male
  • Rats
  • Rats, Wistar
  • Sodium Chloride / administration & dosage
  • Sodium Chloride / toxicity*
  • Ventricular Remodeling / drug effects*

Substances

  • Anti-Inflammatory Agents
  • Sodium Chloride
  • Fludrocortisone