Fasciculols H and I, two lanostane derivatives from Chinese mushroom Naematoloma fasciculare

Chem Biodivers. 2011 Oct;8(10):1864-70. doi: 10.1002/cbdv.201000203.

Abstract

Two new highly oxygenated fasciculol-type lanostane derivatives, fasciculols H and I (1 and 2, resp.), together with five known compounds, 3-7, were isolated from the fruiting bodies of the Chinese toxic mushroom Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic analyses including 2D-NMR (HMBC, HSQC, NOESY, (1)H,(1)H-COSY). Compounds 5-7 were identified for the first time in this mushroom. Compounds 1, 3, 4, and 5 were evaluated for inhibitory activity against human glioma cell line U87 and nuclear factor-κB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / chemistry*
  • Antineoplastic Agents, Alkylating
  • Cell Line, Tumor
  • Central Nervous System Neoplasms / drug therapy
  • Central Nervous System Neoplasms / pathology
  • Drug Screening Assays, Antitumor
  • Fruiting Bodies, Fungal / chemistry
  • Glioma / drug therapy
  • Glioma / pathology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • NF-kappa B p50 Subunit / antagonists & inhibitors
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Alkylating
  • NF-kappa B p50 Subunit
  • NFKB1 protein, human
  • Triterpenes
  • fasciculol H
  • fasciculol I