Abstract
Two new highly oxygenated fasciculol-type lanostane derivatives, fasciculols H and I (1 and 2, resp.), together with five known compounds, 3-7, were isolated from the fruiting bodies of the Chinese toxic mushroom Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic analyses including 2D-NMR (HMBC, HSQC, NOESY, (1)H,(1)H-COSY). Compounds 5-7 were identified for the first time in this mushroom. Compounds 1, 3, 4, and 5 were evaluated for inhibitory activity against human glioma cell line U87 and nuclear factor-κB.
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / chemistry*
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Antineoplastic Agents, Alkylating
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Cell Line, Tumor
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Central Nervous System Neoplasms / drug therapy
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Central Nervous System Neoplasms / pathology
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Drug Screening Assays, Antitumor
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Fruiting Bodies, Fungal / chemistry
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Glioma / drug therapy
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Glioma / pathology
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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NF-kappa B p50 Subunit / antagonists & inhibitors
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Alkylating
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NF-kappa B p50 Subunit
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NFKB1 protein, human
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Triterpenes
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fasciculol H
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fasciculol I