Abstract
Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Carbohydrates* / chemical synthesis
-
Carbohydrates* / chemistry
-
Carbohydrates* / pharmacology
-
Drug Design*
-
Fungi / drug effects*
-
Glycosylation
-
Hydrazines / chemical synthesis
-
Hydrazines / chemistry*
-
Hydrazines / pharmacology
-
Hydrazones / chemical synthesis
-
Hydrazones / chemistry*
-
Hydrazones / pharmacology
-
Molecular Structure
-
Solubility
-
Structure-Activity Relationship
Substances
-
Antifungal Agents
-
Antineoplastic Agents
-
Carbohydrates
-
Hydrazines
-
Hydrazones