Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Muhammad Hanif; Alexey A Nazarov; Anton Legin; Michael Groessl; Vladimir B Arion; Michael A Jakupec; Yury O Tsybin; Paul J Dyson; Bernhard K Keppler; Christian G Hartinger

doi:10.1039/c1cc14713g

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Chem Commun (Camb). 2012 Feb 1;48(10):1475-7. doi: 10.1039/c1cc14713g. Epub 2011 Oct 14.

Authors

Muhammad Hanif¹, Alexey A Nazarov, Anton Legin, Michael Groessl, Vladimir B Arion, Michael A Jakupec, Yury O Tsybin, Paul J Dyson, Bernhard K Keppler, Christian G Hartinger

Affiliation

¹ University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria.

PMID: 22003496
DOI: 10.1039/c1cc14713g

Abstract

Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcysteine / analogs & derivatives
Acetylcysteine / chemistry
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Binding Sites
Cell Line, Tumor
Cell Proliferation / drug effects
Cysteine / chemistry
Dose-Response Relationship, Drug
Glutathione / chemistry
Humans
Maleimides / chemistry*
Models, Molecular
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacology
Ruthenium / chemistry*
Structure-Activity Relationship
Sulfhydryl Compounds / chemistry*

Substances

Antineoplastic Agents
Maleimides
Organometallic Compounds
Sulfhydryl Compounds
maleimide
Ruthenium
Glutathione
Cysteine
Acetylcysteine