Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp

Pritesh Prasad; William Aalbersberg; Klaus-D Feussner; Ryan M Van Wagoner

doi:10.1016/j.tet.2011.08.100

Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp

Tetrahedron. 2011 Nov 4;67(44):8529-8531. doi: 10.1016/j.tet.2011.08.100.

Authors

Pritesh Prasad¹, William Aalbersberg, Klaus-D Feussner, Ryan M Van Wagoner

Affiliation

¹ Institute of Applied Science, Faculty of Science, Technology and Environment, The University of the South Pacific, Laucala Campus, Suva, Fiji Islands.

Abstract

Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 μg/mL.

Abstract

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