Reversible acute kidney injury (AKI) by active removal of serum light chains in an HIV positive patient with myeloma kidney

Clin Nephrol. 2011 Nov;76(5):417-20. doi: 10.5414/cn106569.

Abstract

Background: The association of HIV and myeloma has rarely been reported in the literature. This following case discusses the presentation of acute kidney injury (AKI) in a 53-year-old lady with HIV, subsequently diagnosed with myeloma. Furthermore, we describe recovery of renal function and dialysis independence using a combination of light chain removal by dialysis with a high cut-off dialyzer and chemotherapy.

Investigations: Physical examination, urine, blood tests, renal biopsy, bone marrow aspirate and trephine, US scan.

Diagnosis: Myeloma.

Management: Dialysis and chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / therapy*
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor / blood
  • Female
  • HIV Seropositivity / blood
  • HIV Seropositivity / complications*
  • Humans
  • Immunoglobulin Light Chains / blood*
  • Kidney Neoplasms / blood
  • Kidney Neoplasms / complications*
  • Kidney Neoplasms / drug therapy
  • Middle Aged
  • Multiple Myeloma / blood
  • Multiple Myeloma / complications*
  • Multiple Myeloma / drug therapy
  • Recovery of Function
  • Renal Dialysis*

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Immunoglobulin Light Chains