Detection of an unusual van genotype in a vancomycin-resistant Enterococcus faecium hospital isolate

J Clin Microbiol. 2011 Dec;49(12):4297-8. doi: 10.1128/JCM.05524-11. Epub 2011 Oct 12.

Abstract

We highlight the detection of a rare vanM genotype in Enterococcus faecium. This isolate exhibited a VanB phenotype, with high levels of resistance to vancomycin (MIC, >256 mg/liter) and susceptibility to teicoplanin (MIC, 1 mg/liter). It was, however, vanB negative by PCR. Further screening for other van loci revealed the presence of a complete vanM operon.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / genetics*
  • Enterococcus faecium / isolation & purification
  • Female
  • Genotype
  • Gram-Positive Bacterial Infections / microbiology*
  • Hospitals
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • Phenotype
  • Sequence Analysis, DNA
  • Teicoplanin / pharmacology
  • Vancomycin / pharmacology
  • Vancomycin Resistance*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Teicoplanin
  • Vancomycin

Associated data

  • GENBANK/FJ349556