Abstract
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Anti-Ulcer Agents / pharmacology*
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Anti-Ulcer Agents / therapeutic use
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Cell Line, Tumor
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Diterpene Alkaloids
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Gastric Mucosa / drug effects
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Gastric Mucosa / pathology
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Humans
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Liver / drug effects
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Lung / drug effects
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Male
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Mice
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Naphthoquinones / chemical synthesis*
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification
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Naphthoquinones / pharmacology*
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Stomach / drug effects
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Stomach / pathology
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Stomach Ulcer / chemically induced
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Stomach Ulcer / drug therapy*
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Stomach Ulcer / pathology
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Tabebuia / chemistry
Substances
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Anti-Ulcer Agents
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Diterpene Alkaloids
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Diterpenes
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Naphthoquinones
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diterpene 8(17)-labden-15,19-dioic acid
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lapachol