Background information on the prevalence, clinical characteristics, and differential diagnosis of infantile-onset esotropia is presented. A brief overview of early development of binocularity is also presented to set the stage for management, as well as a sequential treatment plan for two age groups of infantile esotropes: 1) infants and toddlers, and 2) preschool and "older" patients. Flowcharts and case examples are included to highlight the management principles for attaining maximum binocular function.