Abstract
The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.
Keywords:
Cullin4; DCAF-1; HIV; SAMHD1; SIV; Vpx; dendritic cell; macrophage; myeloid cell; ubiquitin.
MeSH terms
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Animals
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Autoimmune Diseases of the Nervous System / virology
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Dendritic Cells / metabolism
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Dendritic Cells / virology
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HIV Infections / virology*
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HIV-1 / genetics
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HIV-1 / physiology*
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HIV-2 / genetics
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HIV-2 / physiology*
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Humans
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Macrophages / metabolism
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Macrophages / virology
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Monomeric GTP-Binding Proteins / genetics
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Monomeric GTP-Binding Proteins / metabolism*
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Myeloid Cells / metabolism*
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Myeloid Cells / virology
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Nervous System Malformations / virology
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SAM Domain and HD Domain-Containing Protein 1
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Simian Immunodeficiency Virus / genetics
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Viral Regulatory and Accessory Proteins / metabolism
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Virus Replication
Substances
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VPX protein, Human immunodeficiency virus 2
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Viral Regulatory and Accessory Proteins
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SAM Domain and HD Domain-Containing Protein 1
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SAMHD1 protein, human
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Monomeric GTP-Binding Proteins
Supplementary concepts
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Aicardi-Goutieres syndrome