Abstract
A trimer of cholic acid made by linking three cholic acid molecules with pentaerythritol via click chemistry serves as the center of an artificial metallohydrolase after the complexation of the triazole groups with a Zn(2+) ion. The invertible amphiphilic cavity can respond to the change in polarity of the solvent media and efficiently modulate the catalytic activity of the artificial enzyme.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholic Acid / chemistry
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Click Chemistry
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Hydrolases / chemistry*
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Hydrolases / metabolism*
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Metalloendopeptidases / chemistry*
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Metalloendopeptidases / metabolism*
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Models, Molecular
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Molecular Structure
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Propylene Glycols / chemistry
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Stereoisomerism
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Triazoles / chemistry
Substances
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Propylene Glycols
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Triazoles
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Hydrolases
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Metalloendopeptidases
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Cholic Acid
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pentaerythritol