Abstract
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkaloids / adverse effects
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Alkaloids / pharmacology*
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Alkaloids / therapeutic use
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Humans
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Inflammation / drug therapy
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Inflammation Mediators / pharmacology*
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Isoquinolines / adverse effects
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Isoquinolines / pharmacology
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Isoquinolines / therapeutic use
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Plant Extracts / adverse effects
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
Substances
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Alkaloids
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Anti-Inflammatory Agents, Non-Steroidal
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Inflammation Mediators
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Isoquinolines
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Plant Extracts