Abstract
Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and β-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cyclohexane Monoterpenes
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Drug Screening Assays, Antitumor
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Evodia / chemistry*
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Fruit / chemistry
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HL-60 Cells
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Humans
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology*
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification
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Nuclear Magnetic Resonance, Biomolecular
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Quinazolines / chemistry
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Quinazolines / isolation & purification*
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Quinazolines / pharmacology*
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Sitosterols / chemistry
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Sitosterols / isolation & purification
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Cyclohexane Monoterpenes
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Indoles
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Monoterpenes
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Quinazolines
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Sitosterols
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limonene-1,2-epoxide
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gamma-sitosterol