MeCP2: phosphorylated locally, acting globally

Neuron. 2011 Oct 6;72(1):3-5. doi: 10.1016/j.neuron.2011.09.017.

Abstract

In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin state in vivo.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain / growth & development*
  • Exploratory Behavior / physiology*
  • Gene Expression Regulation, Developmental / physiology*
  • Genome / physiology*
  • Methyl-CpG-Binding Protein 2 / genetics*
  • Methyl-CpG-Binding Protein 2 / physiology*

Substances

  • Mecp2 protein, mouse
  • Methyl-CpG-Binding Protein 2