Unusual variants of mycosis fungoides

Skinmed. 2011 Jul-Aug;9(4):218-22.

Abstract

Unusual variants of mycosis fungoides (MF) differ substantially from the classical presentation, and most of them resemble other dermatologic diseases. The authors reviewed files of patients with MF who consulted our clinic between November 1995 and June 2010 to evaluate the relative frequency and clinical behavior of these variants. Among 98 patients with MF, 32 (32.65%) had unusual variants. The most common types included follicular MF (31.25%), hypopigmented MF (18.75%), poiquilodermic MF (15.6%), and erythrodermic MF (12.5%). Less common variants included unilesional MF, bullosa MF, ichthyosiform MF, granulomatous slack skin, and pigmented purpura-like MF. Progressive disease and MF-related death were most commonly associated with follicular MF, bullosa MF, and erythrodermic MF.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Angiogenesis Inhibitors / therapeutic use
  • Child
  • Female
  • Humans
  • Immunologic Factors / therapeutic use
  • Interferon-alpha / therapeutic use*
  • Male
  • Middle Aged
  • Mycosis Fungoides / drug therapy*
  • Mycosis Fungoides / pathology*
  • Mycosis Fungoides / radiotherapy
  • Neoplasm Staging
  • PUVA Therapy*
  • Prognosis
  • Retrospective Studies
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / radiotherapy
  • Sunlight
  • Thalidomide / therapeutic use
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Angiogenesis Inhibitors
  • Immunologic Factors
  • Interferon-alpha
  • Thalidomide