Abstract
Fucoxanthin is a non-provitamin A carotenoid contained in brown seaweeds. We found that it suppressed interleukin-17 secretion from CD4(+) T cells under IL-17-producing T (Th17) cell development conditions. By evaluating T cell differentiation in vitro, fucoxanthin and its metabolite fucoxanthinol inhibited T cell differentiation into Th17 cells. This suggests that fucoxanthin can improve inflammatory diseases due to Th17 cells.
MeSH terms
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Animals
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Cell Differentiation / drug effects*
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Forkhead Transcription Factors / genetics
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Gene Expression Regulation / drug effects
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Interleukin-17 / biosynthesis
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Mice
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Nuclear Receptor Subfamily 1, Group F, Member 3 / genetics
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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T-Lymphocytes, Regulatory / cytology*
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T-Lymphocytes, Regulatory / drug effects*
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T-Lymphocytes, Regulatory / metabolism
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Th17 Cells / cytology*
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Th17 Cells / drug effects*
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Th17 Cells / metabolism
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Xanthophylls / pharmacology*
Substances
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Forkhead Transcription Factors
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Foxp3 protein, mouse
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Interleukin-17
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Nuclear Receptor Subfamily 1, Group F, Member 3
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RNA, Messenger
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Xanthophylls
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fucoxanthin