The term severe pathology of mood and behaviors includes a wide range of clinical presentations. A nosographic entity which is not clearly defined, the defiance is to search for scales that identify, using the same core phenotype, the patients with Emotional Dysregulation or Bipolar Spectrum Disorders. The Child Behavior Check List (CBCL) and their subscales seem to be helpful in identifying severe psychopathology of childhood, characterized by affective, behavioral and cognitive dysregulation. The family background and medical comorbidity (abnormal thyroidprofile) seem to be related to special entity diagnosed by the clinician.