Abstract
Three new isopimarane diterpenes 7β-hydroxy-19α-methylmalonyloxy-isopimara-8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15-diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Candida albicans / drug effects
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Candida tropicalis / drug effects
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Chlorophyta / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
Substances
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7beta-hydroxy-14-oxo-19alpha-methylmalonyloxy-isopimara-9(11),15-diene
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7beta-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid
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7beta-hydroxy-19alpha-methylmalonyloxy-isopimara-8(14),15-diene
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Anti-Bacterial Agents
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Antifungal Agents
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Diterpenes