Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead

Keith F Tipton; Gavin P Davey; Andrew G McDonald

doi:10.1016/B978-0-12-386467-3.00003-0

Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead

Int Rev Neurobiol. 2011:100:43-64. doi: 10.1016/B978-0-12-386467-3.00003-0.

Authors

Keith F Tipton¹, Gavin P Davey, Andrew G McDonald

Affiliation

¹ Department of Biochemistry, Trinity College, Dublin, Ireland.

PMID: 21971002
DOI: 10.1016/B978-0-12-386467-3.00003-0

Abstract

Monoamine oxidase (MAO) inhibitors have proven to be valuable tools in pharmacology and therapeutics. This account concerns the behavior of the different types of reversible inhibitor and how an understanding of the kinetic mechanisms of MAO may help in their design.

Publication types

Review

MeSH terms

Animals
Humans
Kinetics
Monoamine Oxidase / chemistry*
Monoamine Oxidase / metabolism*
Monoamine Oxidase / pharmacokinetics
Monoamine Oxidase Inhibitors / chemical synthesis
Monoamine Oxidase Inhibitors / metabolism
Monoamine Oxidase Inhibitors / pharmacology*
Structure-Activity Relationship

Substances

Monoamine Oxidase Inhibitors
Monoamine Oxidase