Pathogenesis and management of hypertension after kidney transplantation

J Hypertens. 2011 Dec;29(12):2283-94. doi: 10.1097/HJH.0b013e32834bd1e7.

Abstract

Arterial hypertension is frequently encountered after renal transplantation and is associated not only with increased cardiovascular complications but also with decreased allograft survival. Adequate blood pressure control is, thus, as essential as immunologic surveillance for the long-term transplant care. Nevertheless, randomized control trials assessing treatment targets in these patients are not available and most of the evidence comes from studies in patients with native chronic kidney disease or the general population. In this regard, the renal transplant recipient is treated according to recommendations that are applicable to nontransplanted individuals at high cardiovascular risk. However, the accepted treatment targets for the nontransplanted population are recently being disputed and this makes the management of posttransplant hypertension even more challenging.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Graft Survival
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / etiology*
  • Immunosuppression Therapy
  • Kidney Failure, Chronic / drug therapy
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation / adverse effects*
  • Postoperative Complications
  • Randomized Controlled Trials as Topic
  • Renin-Angiotensin System / drug effects
  • Time Factors

Substances

  • Antihypertensive Agents