Purpose: To describe a systemic lupus erythematosus (SLE) relapse, which presented as frosted branch retinal angiitis.
Design: Clinical case report.
Methods: A 16-year-old female patient had an SLE relapse that appeared as frosted branch angiitis while being treated with deflazacort and azathioprine.
Results: Complete resolution of the vasculitis was achieved with a 3-day course of pulsed intravenous methylprednisolone and oral prednisone 3 weeks later.
Conclusions: Even with proper immunosuppressive treatment, SLE can relapse. This case presented as frosted branch retinal angiitis, which is a clinical picture that is rarely described in SLE.