Abstract
Extended-spectrum β-lactamases (ESBLs) belonging to the TEM and SHV families were investigated in 583 ESBL-producing Enterobacteriaceae collected at the clinical microbiology laboratories of 11 teaching Italian hospitals. By molecular analysis TEM-type and SHV-type ESBLs were confirmed on 154 and 74 isolates, respectively. High variability was found among TEM-types β-lactamases with the following variants: TEM-5, TEM-6, TEM-12, TEM-15, TEM-24, TEM-26, TEM-29, TEM-52, TEM-92, TEM-134, and TEM-149. Among SHV variants, SHV-2a, SHV-5, SHV-12, and SHV-28 have been detected. The most widespread variants are TEM-52/92 and SHV-12.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / genetics
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology
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Hospitals, Teaching / statistics & numerical data
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Humans
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Italy / epidemiology
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Microbial Sensitivity Tests
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beta-Lactam Resistance
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
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beta-Lactams / pharmacology
Substances
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beta-Lactams
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TEM-52 beta-lactamase
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beta-lactamase SHV-12
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beta-Lactamases