Abstract
In this report, we demonstrate how UV-light exposure can enhance DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline about 40 times in comparison to nonirradiated conditions. In addition, new aspects regarding their DNA binding properties, as well as the mechanism of the cleavage reaction, were also investigated.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Copper / chemistry
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Copper / metabolism
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DNA / chemistry
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DNA / metabolism
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DNA Cleavage / drug effects*
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DNA Cleavage / radiation effects
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Humans
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Intercalating Agents / chemistry
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Intercalating Agents / metabolism
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Intercalating Agents / pharmacology*
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Neoplasms / drug therapy
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology*
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Phenanthrolines / chemistry*
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Phenanthrolines / metabolism
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Photochemical Processes / drug effects
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Photochemical Processes / radiation effects
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Photochemotherapy / methods
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / metabolism
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Photosensitizing Agents / pharmacology*
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Plasmids / chemistry
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Plasmids / metabolism
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Tetracyclines / chemistry*
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Tetracyclines / metabolism
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Ultraviolet Rays
Substances
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Intercalating Agents
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Organometallic Compounds
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Phenanthrolines
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Photosensitizing Agents
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Tetracyclines
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Copper
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DNA
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1,10-phenanthroline