Photoinduced DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline

Inorg Chem. 2011 Nov 7;50(21):10519-21. doi: 10.1021/ic201349s. Epub 2011 Oct 4.

Abstract

In this report, we demonstrate how UV-light exposure can enhance DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline about 40 times in comparison to nonirradiated conditions. In addition, new aspects regarding their DNA binding properties, as well as the mechanism of the cleavage reaction, were also investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Copper / chemistry
  • Copper / metabolism
  • DNA / chemistry
  • DNA / metabolism
  • DNA Cleavage / drug effects*
  • DNA Cleavage / radiation effects
  • Humans
  • Intercalating Agents / chemistry
  • Intercalating Agents / metabolism
  • Intercalating Agents / pharmacology*
  • Neoplasms / drug therapy
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology*
  • Phenanthrolines / chemistry*
  • Phenanthrolines / metabolism
  • Photochemical Processes / drug effects
  • Photochemical Processes / radiation effects
  • Photochemotherapy / methods
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / metabolism
  • Photosensitizing Agents / pharmacology*
  • Plasmids / chemistry
  • Plasmids / metabolism
  • Tetracyclines / chemistry*
  • Tetracyclines / metabolism
  • Ultraviolet Rays

Substances

  • Intercalating Agents
  • Organometallic Compounds
  • Phenanthrolines
  • Photosensitizing Agents
  • Tetracyclines
  • Copper
  • DNA
  • 1,10-phenanthroline