Background: Ocular function is modified with hormone therapy; however, reports in literature are highly controversial.
Objective: To analyze how hormone therapy modifies intraocular pressure and the number of tears shed by Mexican women.
Patients and methods: Eighteen postmenopausal women were studied and randomly divided into two groups, according to the treatment they received: group 1, conjugated equine estrogens (CEE) 0.625 mg/day (n=9) (hysterectomized women with bilateral oophorectomy) and group 2, CEE 0.625 mg/day plus chlormadinone 1 mg/day (n=9) (women with intact uterus). Changes in intraocular pressure and Schirmer's test were analyzed at baseline and three months after the treatment. Statistical analysis was performed with Student's t test for independent and paired samples.
Results: There were no significant differences in intraocular pressure or Schirmer's test among groups, neither when comparing baseline and final results in each group independently.
Conclusion: We could not demonstrate the effect of hormone replacement therapy on intraocular pressure and on Schirmer's test after three months of its administration.