Molecular modeling study on the disassembly of dendrimers designed as potential antichagasic and antileishmanial prodrugs

J Mol Model. 2012 May;18(5):2257-69. doi: 10.1007/s00894-011-1244-8. Epub 2011 Oct 2.

Abstract

A molecular modeling study was carried out to investigate the most likely enzymatic disassembly mechanism of dendrimers that were designed as potential antichagasic and antileishmanial prodrugs. The models contained myo-inositol (core), L-malic acid (spacer), and active agents such as 3-hydroxyflavone, quercetin, and hydroxymethylnitrofurazone (NFOH). A theoretical approach that considered one, two, or three branches has already been performed and reported by our research group; the work described herein focused on four (models A and B), five, or six branches, and considered their physicochemical properties, such as spatial hindrance, electrostatic potential mapping, and the lowest unoccupied molecular orbital energy (E(LUMO)). The findings suggest that the carbonyl group next to the myo-inositol is the most promising ester breaking point.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemistry*
  • Flavonoids / chemistry
  • Inositol / chemistry
  • Malates / chemistry
  • Molecular Dynamics Simulation*
  • Nitrofurazone / analogs & derivatives
  • Nitrofurazone / chemistry
  • Prodrugs / chemistry*
  • Quercetin / chemistry
  • Static Electricity
  • Thermodynamics
  • Trypanocidal Agents / chemistry*

Substances

  • Dendrimers
  • Flavonoids
  • Malates
  • Prodrugs
  • Trypanocidal Agents
  • hydroxymethylnitrofurazone
  • Inositol
  • malic acid
  • Quercetin
  • Nitrofurazone
  • 3-hydroxyflavone