Abstract
We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Dietary Supplements / analysis
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Drug Contamination*
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Erectile Dysfunction / drug therapy*
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Humans
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Imidazoles / analysis*
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Imidazoles / chemical synthesis
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Imidazoles / chemistry*
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Imidazoles / pharmacology
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Male
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Molecular Structure
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Phosphodiesterase 5 Inhibitors / analysis*
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Phosphodiesterase 5 Inhibitors / chemical synthesis
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Phosphodiesterase 5 Inhibitors / chemistry*
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Phosphodiesterase 5 Inhibitors / pharmacology
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Piperazines / chemistry
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Purines / chemistry
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Sildenafil Citrate
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Sulfones / chemistry
Substances
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Imidazoles
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Phosphodiesterase 5 Inhibitors
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Piperazines
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Purines
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Sulfones
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mutaprodenafil
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aildenafil
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Sildenafil Citrate