Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis

Chem Pharm Bull (Tokyo). 2011;59(10):1314-6. doi: 10.1248/cpb.59.1314.

Abstract

We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dietary Supplements / analysis
  • Drug Contamination*
  • Erectile Dysfunction / drug therapy*
  • Humans
  • Imidazoles / analysis*
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Imidazoles / pharmacology
  • Male
  • Molecular Structure
  • Phosphodiesterase 5 Inhibitors / analysis*
  • Phosphodiesterase 5 Inhibitors / chemical synthesis
  • Phosphodiesterase 5 Inhibitors / chemistry*
  • Phosphodiesterase 5 Inhibitors / pharmacology
  • Piperazines / chemistry
  • Purines / chemistry
  • Sildenafil Citrate
  • Sulfones / chemistry

Substances

  • Imidazoles
  • Phosphodiesterase 5 Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • mutaprodenafil
  • aildenafil
  • Sildenafil Citrate