Halioxepine, a new meroditerpene from an Indonesian sponge Haliclona sp

Chem Pharm Bull (Tokyo). 2011;59(10):1311-3. doi: 10.1248/cpb.59.1311.

Abstract

Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC50 4.8 µg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 3.2 µg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / analysis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Biological Factors
  • Cell Line, Tumor
  • Diterpenes / analysis
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Drug Evaluation, Preclinical
  • Drug Screening Assays, Antitumor
  • Haliclona / chemistry*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Antineoplastic Agents
  • Biological Factors
  • Diterpenes
  • halioxepine