Abstract
We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology*
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Antimicrobial Cationic Peptides / chemical synthesis
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Antimicrobial Cationic Peptides / pharmacology*
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Biomimetic Materials
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Candida albicans / drug effects
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Cell Membrane / drug effects
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Drug Resistance, Multiple, Bacterial
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Escherichia coli / drug effects
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Gram-Positive Bacteria / drug effects
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Klebsiella pneumoniae / drug effects
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Microbial Sensitivity Tests
Substances
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Anti-Infective Agents
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Antimicrobial Cationic Peptides