Abstract
A series of novel (thio)ureas containing the pyrimidinyl group was designed and synthesized. Their in-vitro antitumor activity against different human tumor cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further studies on structure modification.
2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Humans
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
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Thiourea / chemical synthesis
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Thiourea / chemistry
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Thiourea / pharmacology*
Substances
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Antineoplastic Agents
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Pyrimidines
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Thiourea