Synthesis and biological evaluation of novel (thio)urea derivatives as potential antitumor agents

Arch Pharm (Weinheim). 2011 Nov;344(11):741-4. doi: 10.1002/ardp.201000267. Epub 2011 Sep 29.

Abstract

A series of novel (thio)ureas containing the pyrimidinyl group was designed and synthesized. Their in-vitro antitumor activity against different human tumor cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further studies on structure modification.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Pyrimidines / chemical synthesis
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology*
  • Structure-Activity Relationship
  • Thiourea / chemical synthesis
  • Thiourea / chemistry
  • Thiourea / pharmacology*

Substances

  • Antineoplastic Agents
  • Pyrimidines
  • Thiourea