Syntheses and self-assembling behaviors of pentagonal conjugates of tryptophane zipper-forming peptide

Kazunori Matsuura; Kazuya Murasato; Nobuo Kimizuka

doi:10.3390/ijms12085187

Syntheses and self-assembling behaviors of pentagonal conjugates of tryptophane zipper-forming peptide

Int J Mol Sci. 2011;12(8):5187-99. doi: 10.3390/ijms12085187. Epub 2011 Aug 15.

Authors

Kazunori Matsuura¹, Kazuya Murasato, Nobuo Kimizuka

Affiliation

¹ Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan; E-Mails: ma2ra-k@mail.cstm.kyushu-u.ac.jp (K.M.); n-kimi@mail.cstm.kyushu-u.ac.jp (N.K.).

Abstract

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.

Keywords: nanofiber; pentagonal conjugate; self-assembly; tryptophane zipper peptide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Circular Dichroism
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptides / chemical synthesis
Peptides / chemistry*
Protein Folding*
Protein Multimerization*
Protein Structure, Secondary
Tryptophan / chemistry*
Water / chemistry

Substances

Peptides
Water
Tryptophan