Abstract
Linezolid has proven valuable in musculoskeletal infections, however, failure and resistance have been described and toxicity is worrisome when more than 28 days are necessary. We describe the first 5 cases in whom linezolid trough serum concentrations were weekly measured and its relationship with clinical outcome and toxicity.
MeSH terms
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Acetamides / blood*
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Acetamides / therapeutic use*
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Adult
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Aged
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Anti-Bacterial Agents / blood*
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Anti-Bacterial Agents / therapeutic use*
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Drug Monitoring
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Female
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Gram-Positive Bacterial Infections / drug therapy
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Cocci
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Humans
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Linezolid
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Male
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Middle Aged
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Musculoskeletal Diseases / drug therapy
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Musculoskeletal Diseases / microbiology
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Orthopedic Procedures
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Oxazolidinones / blood*
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Oxazolidinones / therapeutic use*
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Treatment Outcome
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid