Usefulness of monitoring linezolid trough serum concentration in prolonged treatments

Rev Esp Quimioter. 2011 Sep;24(3):151-3.

Abstract

Linezolid has proven valuable in musculoskeletal infections, however, failure and resistance have been described and toxicity is worrisome when more than 28 days are necessary. We describe the first 5 cases in whom linezolid trough serum concentrations were weekly measured and its relationship with clinical outcome and toxicity.

MeSH terms

  • Acetamides / blood*
  • Acetamides / therapeutic use*
  • Adult
  • Aged
  • Anti-Bacterial Agents / blood*
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Monitoring
  • Female
  • Gram-Positive Bacterial Infections / drug therapy
  • Gram-Positive Bacterial Infections / microbiology
  • Gram-Positive Cocci
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Musculoskeletal Diseases / drug therapy
  • Musculoskeletal Diseases / microbiology
  • Orthopedic Procedures
  • Oxazolidinones / blood*
  • Oxazolidinones / therapeutic use*
  • Prosthesis-Related Infections / drug therapy*
  • Prosthesis-Related Infections / microbiology
  • Treatment Outcome

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid