The integral medical supervision of 320 patients with epileptic seizures developed in the cases of cerebral ischemic lesion revealed the predominance of focal epileptic seizures and cortical ischemic pathology, and the correlation between the time of the clinical manifestation of seizures and the stroke subtype. The critical significance of stenoses and occlusions and the reduction of cerebrovascular reactivity in the vertebro-basilar basin were observed in patients with epileptic seizures due to the brain ischemic lesion compared with patients of the control group.