Abstract
Clinical and laboratory data are described for two siblings who both developed adult T-cell leukemia/lymphoma resulting from infection by human T lymphotropic virus type I (HTLV-I). These findings suggest that genetic factors or virus-specific factors may determine which HTLV-I-infected individuals will develop leukemia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Bone Marrow / pathology
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Enzyme-Linked Immunosorbent Assay
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Female
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HTLV-I Infections / complications
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Human T-lymphotropic virus 1 / isolation & purification
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Humans
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Leukemia, T-Cell / etiology
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Leukemia, T-Cell / genetics*
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Leukemia, T-Cell / pathology
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Lymph Nodes / pathology
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Lymphoma / etiology
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Lymphoma / genetics*
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Lymphoma / pathology
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Male
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Neoplasms, Multiple Primary / genetics*
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Nucleic Acid Hybridization
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Polymerase Chain Reaction
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Radiography
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Skull / diagnostic imaging