Serum kinetics of soluble triggering receptor expressed on myeloid cells-1 differs in relation to the type of arthroplasty

Biomarkers. 2011 Nov;16(7):600-4. doi: 10.3109/1354750X.2011.613122. Epub 2011 Sep 26.

Abstract

Context: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) participates in the inflammatory process.

Purpose: To describe changes of sTREM-1 in the serum after hemiarthroplasty (HA) and total hip arthroplasty (THA).

Methods: Serial blood samples were drawn from 122 patients with hip fracture. Interleukin-6 (IL-6), sTREM-1, and C-reactive protein (CRP) were measured.

Results: IL-6 and CRP were similarly increased after both HA and THA. sTREM-1 was increased early in HA and late after THA. The only parameter that was higher among patients who developed systemic inflammatory response syndrome was IL-6.

Conclusions: Kinetics of sTREM-1 differs among patients undergoing HA of the hip and those undergoing THA.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Arthroplasty / methods*
  • C-Reactive Protein / analysis
  • Female
  • Hip Fractures / blood*
  • Hip Fractures / surgery*
  • Humans
  • Immunoenzyme Techniques
  • Interleukin-6 / blood
  • Kinetics
  • Male
  • Membrane Glycoproteins / blood*
  • Receptors, Immunologic / blood*
  • Triggering Receptor Expressed on Myeloid Cells-1

Substances

  • Interleukin-6
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1
  • C-Reactive Protein