Expansion of the child welfare evidence base is a major challenge. The field must establish how organizational systems and practice techniques yield outcomes for children and families. Needed research must be grounded in practice and must engage practitioners and administrators via participatory evaluation. The extent to which successful practices are transferable is also challenged by the diversity of child welfare systems. The U.S. Department of Health and Human Services' Children's Bureau funded Quality Improvement Centers (QICs) that were designed to promote collaborative, multisite research that would address these evaluation needs. This article, based on the findings of a regional and a national QIC, describes the challenges facing research collaboration and the strategies for achieving success.