Abstract
There is currently limited evidence on the safety and efficacy of novel oral anticoagulants in patients with mechanical heart valves. This case report describes a patient with a St Jude aortic valve replacement who suffered valve thrombosis and an embolic stroke when anti-coagulated with the direct thrombin inhibitor dabigatran etexilate.
Copyright © 2011 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All rights reserved.
MeSH terms
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Aortic Valve / pathology
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Aortic Valve / physiopathology
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Aortic Valve / surgery
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Aortic Valve Stenosis / surgery
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Benzimidazoles / administration & dosage*
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Benzimidazoles / adverse effects
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Blood Coagulation / drug effects
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Dabigatran
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Drug Resistance
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Echocardiography, Transesophageal / methods
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Fibrinolytic Agents / administration & dosage
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Fibrinolytic Agents / adverse effects
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Heart Valve Prosthesis / adverse effects*
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Heart Valve Prosthesis Implantation* / instrumentation
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Heart Valve Prosthesis Implantation* / methods
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Humans
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Intracranial Embolism / etiology*
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Male
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Middle Aged
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Postoperative Complications* / blood
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Postoperative Complications* / etiology
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Postoperative Complications* / physiopathology
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Risk Adjustment
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Severity of Illness Index
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Thrombosis* / etiology
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Thrombosis* / physiopathology
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Tomography, X-Ray Computed / methods
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Treatment Outcome
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beta-Alanine / administration & dosage
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beta-Alanine / adverse effects
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beta-Alanine / analogs & derivatives*
Substances
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Benzimidazoles
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Fibrinolytic Agents
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beta-Alanine
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Dabigatran