Thrombosis on a Mechanical Aortic Valve whilst Anti-coagulated With Dabigatran

Heart Lung Circ. 2012 Jan;21(1):53-5. doi: 10.1016/j.hlc.2011.08.014. Epub 2011 Sep 19.

Abstract

There is currently limited evidence on the safety and efficacy of novel oral anticoagulants in patients with mechanical heart valves. This case report describes a patient with a St Jude aortic valve replacement who suffered valve thrombosis and an embolic stroke when anti-coagulated with the direct thrombin inhibitor dabigatran etexilate.

Publication types

  • Case Reports

MeSH terms

  • Aortic Valve / pathology
  • Aortic Valve / physiopathology
  • Aortic Valve / surgery
  • Aortic Valve Stenosis / surgery
  • Benzimidazoles / administration & dosage*
  • Benzimidazoles / adverse effects
  • Blood Coagulation / drug effects
  • Dabigatran
  • Drug Resistance
  • Echocardiography, Transesophageal / methods
  • Fibrinolytic Agents / administration & dosage
  • Fibrinolytic Agents / adverse effects
  • Heart Valve Prosthesis / adverse effects*
  • Heart Valve Prosthesis Implantation* / instrumentation
  • Heart Valve Prosthesis Implantation* / methods
  • Humans
  • Intracranial Embolism / etiology*
  • Male
  • Middle Aged
  • Postoperative Complications* / blood
  • Postoperative Complications* / etiology
  • Postoperative Complications* / physiopathology
  • Risk Adjustment
  • Severity of Illness Index
  • Thrombosis* / etiology
  • Thrombosis* / physiopathology
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome
  • beta-Alanine / administration & dosage
  • beta-Alanine / adverse effects
  • beta-Alanine / analogs & derivatives*

Substances

  • Benzimidazoles
  • Fibrinolytic Agents
  • beta-Alanine
  • Dabigatran